Fluid Mechanics & Aerodynamics

Fluid Mechanics & Aerodynamics

Investigating the Effect of Holed Vibrating Disc Diameter in Creating Strong Mixing with Low Energy Dissipation Rate in a Novel Stirred Reactor

Document Type : Original Article

Authors
s.m h 1
Sepehr Govara 2
Masoud Soleimani 3
1 Professor, University of Science and Technology, Tehran, Iran
2 PhD student, Iran University of Science and Technology, Tehran, Iran
3 Professor, Tarbiat Modares University, Tehran, Iran
Abstract
The use of stirred tanks is very common in various industries due to their efficiency, proper mixing, and low cost. Usually, the stirrers used in these devices are impeller-type, which perform the mixing with a rotary movement. One of the most important problems of the impeller stirrers is the application of high shear stress, which is destructive in biological and sensitive applications. In this research, a novel laboratory-scale stirred reactor has been introduced, which provides mixing at low shear stress levels by using a perforated vibrating disc. Experimental investigation and numerical simulation of the stirred reactor have been done focusing on the effect of disc diameter. In the experimental section, Raji cell, as one of the most sensitive living particles, has been cultured in this stirred reactor using discs with a diameter of 25 and 65 (mm). Experimental results show the decreasing effect of disc diameter on cell growth indices, including the natural logarithm of maximum cell concentration and productivity. These indicators when using a 25 (mm) disc are high and about 13.2 and 4685 (cells/hmL), respectively, which indicates the proper performance of this stirred reactor in cell culture. The results of the numerical simulation show a tenfold increase in the energy dissipation rate factor with an increase in the disc diameter from 25 to 65 (mm), which indicates the logical agreement of the numerical simulation results with the experimental data.
Keywords
Vibrating disc
Shear stress
Reactor
Numerical simulation
Cell culture

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Fluid Mechanics & Aerodynamics
Volume 13, Issue 2 - Serial Number 34
Autumn and winter
November 2024
Pages 43-54

  • Receive Date 16 May 2024
  • Revise Date 14 September 2024
  • Accept Date 12 November 2024
  • Publish Date 01 December 2024