The significance of employing micro- and nano-scale dimensions is increasingly recognized, with one key advantage being the reduction in overall radiator weight. This research primarily aims to investigate crucial dimensionless fluid flow parameters such as the friction factor and Nusselt number. These parameters are compared across various flow rates and geometries, ultimately identifying the geometry with the most favorable thermal performance. One approach to enhance heat transfer performance in microchannels involves novel geometries. In this study, a sinusoidal corrugated microchannel was employed. To improve heat transfer, geometric parameters such as wavelength, wave amplitude, and aperture height were investigated. Subsequently, this optimized geometry with misaligned walls was compared against both aligned-wall corrugated geometries and an airfoil-shaped geometry based on the NACA0012 profile. The analysis assumes steady, laminar, and incompressible flow conditions. The outlet was subjected to a pressure outlet boundary condition, and the walls experienced a no-slip condition and convective heat transfer from the surrounding 300 K cold air. In the corrugated microchannel radiators examined in this study, heat transfer enhancement of 200% to 350% was achieved compared to mini-channel dimensions, along with a 58% weight reduction compared to a reference radiator. The airfoil-shaped geometry exhibited a 33% improvement in thermal performance compared to the aligned-wall geometry and a 49% improvement in fluid-dynamic performance compared to the misaligned corrugated geometry. Furthermore, a study of fouling, comparing average velocities at a distance of 150 micrometers near the microchannel wall, revealed values 6.6 times higher than those observed in the mini-channel walls.