آنالیز دینامیکی جریان سیال و انتخاب نانوذرات بهینه برای هندسه‌ای با 50% گرفتگی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشیار،دانشگاه امام علی (ع)، تهران، ایران.

2 کارشناسی ارشد، دانشگاه صنعتی شریف، تهران، ایران.

3 دکتری ، دانشگاه امام علی (ع) ، تهران، ایران.

4 استادیار ، دانشگاه امام علی (ع) ، تهران، ایران.

چکیده

لوله‌های انتقال سیال نقش بسیار کلیدی در ارتباط اجزای مختلف سامانه‌های سیالاتی به‌خصوص سیستم سیالاتی بدن انسان بر عهده‌دارند. انسداد تنها لوله‌های خون‌رسانی از قلب به مغز (رگ‌های کاروتید) از مهم‌ترین علل سکته مغزی است؛ بنابراین درمان گرفتگی‌های رگ کاروتید گامی بزرگ در جهت پیشگیری از سکته مغزی و بهبود عملکرد مغز و بدن است. دارورسانی هدفمند به‌وسیله نانوذرات بهینه‌شده ازنظر اندازه و تعداد، به‌روزترین روش برای رساندن بهینه دارو به نواحی آسیب‌دیده رگ است. در این پژوهش برای بررسی نانوذرات بهینه، هندسه‌ای با گرفتگی 50% در نظر گرفته‌ می‌شود. پس از شبیه‌سازی جریان سیال در نواحی آسیب‌دیده و انتخاب نانوذرات Fe3O4@MOF با لیگاند سطحی مناسب به‌عنوان حامل دارویی هدفمند با اندازه‌های nm100، nm200، nm400، nm600، nm800 و nm1000 و تعداد تزریق 100، 300 و 500 ذره در هر سیکل، شبیه‌سازی‌های مربوط به نانوذرات صورت می‌گیرد. درنهایت نتیجه می‌شود ذراتی با اندازه nm100 و تعداد تزریق 300 ذره در هر سیکل بیشترین مقدار چسبندگی به ناحیه هدف را دارند و همچنین ذراتی با اندازه nm800 و تعداد تزریق 100 ذره در هر سیکل دارای ظرفیت انتقال دارویی سطحی و حجمی بالاتری هستند. بهینه‌سازی تعداد ذرات تزریق‌شده موجب کاهش چشمگیر هزینه‌ها و اثرات جانبی می‌شود.

کلیدواژه‌ها

عنوان مقاله [English]

Dynamic analysis of fluid flow and selection of optimal nanoparticles for a geometry with 50% blockage

نویسندگان [English]

  • amirhamzeh farajollahi 1
  • Ali Amani 2
  • jalal shojaei 3
  • Mohsen Rostami 4
1 Associate Professor, Imam Ali University (AS), Tehran, Iran.
2 Master's degree, Sharif University of Technology, Tehran, Iran.
3 Ph.D., Imam Ali University (AS), Tehran, Iran.
4 Assistant Professor, Imam Ali University (AS), Tehran, Iran.
چکیده [English]

Fluid transfer pipes play a key role in connecting different components of fluid systems, especially within the human body's circulatory system. Blockage of the carotid arteries, the primary blood vessels carrying blood from the heart to the brain, is a leading cause of stroke. Therefore, treating carotid artery blockages represents a significant stride in stroke prevention and the enhancement of brain and body function. The most contemporary approach for delivering drugs precisely to damaged arterial regions involves the use of nanoparticles that are fine-tuned in terms of both size and quantity. In this study, a geometry with 50% occlusion is utilized to examine the optimal nanoparticles. Following simulations of fluid flow in the damaged areas and the selection of Fe3O4@MOF nanoparticles with an appropriate surface ligand as a targeted drug carrier, in sizes ranging from 100 to 1000 nm, and with injection numbers of 100, 300, and 500 particles per cycle, the nanoparticle simulations are conducted. Ultimately, the results indicate that particles measuring 100 nm in size, with an injection number of 300 particles per cycle, exhibit the highest degree of adhesion to the target area. Additionally, particles sized at 800 nm, injected at a rate of 100 particles per cycle, demonstrate superior surface and volume drug transfer capabilities. Optimizing the quantity of injected particles notably reduces costs and mitigates potential side effects

کلیدواژه‌ها [English]

  • Fluid transfer pipes
  • Damaged areas
  • Targeted drug delivery
  • Optimized nanoparticles
  • Carotid artery

Smiley face

https://creativecommons.org/licenses/by/4.0/

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مکانیک سیالات و آیرودینامیک
دوره 12، شماره 2 - شماره پیاپی 32
پاییز و زمستان 1402
اسفند 1402
صفحه 13-31

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سابقه مقاله

  • تاریخ دریافت: 23 تیر 1402
  • تاریخ بازنگری: 20 آذر 1402
  • تاریخ پذیرش: 18 دی 1402
  • تاریخ انتشار: 30 بهمن 1402

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