بررسی اثر قطر دیسک ارتعاشی حفره‌دار در ایجاد اختلاط قوی با نرخ اضمحلال انرژی پایین در یک رآکتور همزن جدید

نوع مقاله : مقاله پژوهشی

نویسندگان

1 استاد،دانشگاه علم و صنعت، تهران، ایران

2 دانشجوی دکتری،دانشگاه علم و صنعت ایران، تهران، ایران

3 استاد، دانشگاه تربیت مدرس، تهران، ایران

چکیده

کاربرد مخزن­های همزن در صنایع مختلف به دلیل کارایی، اختلاط مناسب و هزینه کم بسیار گسترده است. به طور معمول همزن­های استفاده شده در این دستگاه­ها از نوع پروانه­ای است که با حرکت چرخشی عمل اختلاط را انجام می­دهند. یکی از مهم‌ترین مشکلات این نوع همزن­ها اعمال تنش برشی بالا است که در کاربردهای زیست­فناوری و حساس، مخرب است. در این پژوهش رآکتور همزن جدیدی در مقیاس آزمایشگاهی معرفی شده است که با استفاده از دیسک ارتعاشی حفره­دار اختلاط را در سطوح تنش برشی پایین فراهم می­آورد. بررسی آزمایشگاهی و شبیه­سازی عددی این رآکتور همزن با محوریت بررسی اثر قطر دیسک انجام شده است. در بخش آزمایشگاهی، سلول راجی به­عنوان یکی از حساس­ترین ذرات زنده در این رآکتور همزن و با دیسک­های به قطر (mm) 25 و 65 کشت داده شده است. نتایج آزمایشگاهی نشان­دهنده اثر کاهشی قطر دیسک بر شاخص­های رشد سلول شامل لگاریتم طبیعی بیشینه غلظت سلول و بهره­وری است. این شاخص­ها، هنگام استفاده از دیسک (mm) 25 بالا و به ترتیب 2/13 و (cells/hmL) 4685 است که  عملکرد مناسب این رآکتور همزن را در کشت سلول نشان می­دهد. نتایج حاصل از شبیه­سازی عددی نشان­دهنده افزایش ده برابری فاکتور نرخ اضمحلال انرژی با افزایش قطر دیسک از (mm) 25 به 65 است که تطابق منطقی نتایج حاصل از شبیه­سازی عددی با نتایج آزمایشگاهی را نشان می­دهد.

کلیدواژه‌ها

عنوان مقاله [English]

Investigating the Effect of Holed Vibrating Disc Diameter in Creating Strong Mixing with Low Energy Dissipation Rate in a Novel Stirred Reactor

نویسندگان [English]

  • s.m h 1
  • Sepehr Govara 2
  • Masoud Soleimani 3
1 Professor, University of Science and Technology, Tehran, Iran
2 PhD student, Iran University of Science and Technology, Tehran, Iran
3 Professor, Tarbiat Modares University, Tehran, Iran
چکیده [English]

The use of stirred tanks is very common in various industries due to their efficiency, proper mixing, and low cost. Usually, the stirrers used in these devices are impeller-type, which perform the mixing with a rotary movement. One of the most important problems of the impeller stirrers is the application of high shear stress, which is destructive in biological and sensitive applications. In this research, a novel laboratory-scale stirred reactor has been introduced, which provides mixing at low shear stress levels by using a perforated vibrating disc. Experimental investigation and numerical simulation of the stirred reactor have been done focusing on the effect of disc diameter. In the experimental section, Raji cell, as one of the most sensitive living particles, has been cultured in this stirred reactor using discs with a diameter of 25 and 65 (mm). Experimental results show the decreasing effect of disc diameter on cell growth indices, including the natural logarithm of maximum cell concentration and productivity. These indicators when using a 25 (mm) disc are high and about 13.2 and 4685 (cells/hmL), respectively, which indicates the proper performance of this stirred reactor in cell culture. The results of the numerical simulation show a tenfold increase in the energy dissipation rate factor with an increase in the disc diameter from 25 to 65 (mm), which indicates the logical agreement of the numerical simulation results with the experimental data.

کلیدواژه‌ها [English]

  • Vibrating disc
  • Shear stress
  • Reactor
  • Numerical simulation
  • Cell culture

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مکانیک سیالات و آیرودینامیک
دوره 13، شماره 2 - شماره پیاپی 33
پاییز و زمستان 1403
آذر 1403
صفحه 43-54

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  • تاریخ دریافت: 27 اردیبهشت 1403
  • تاریخ بازنگری: 24 شهریور 1403
  • تاریخ پذیرش: 22 آبان 1403
  • تاریخ انتشار: 11 آذر 1403

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